Comprehensive 2D/3D RAS Cell Panel for Mutation-Specific Inhibitor Profiling: From Screening to Mechanistic Validation
Targeting drug profiling using cancer cell line panels is a powerful approach for evaluating efficacy, selectivity, and mechanism of action of emerging therapeutics.
Integrated DRUG-seq and Cell Painting Profiling of JUMP MoA Compounds in U2OS and HepG2 Cells
DRUG-seq captures broader biological responses, whereas Cell Painting provides complementary morphological insights and consistent cross-cell-type clustering. Integrating both assays enhances mechanism-of-action inference and cross-platform validation.
Total DRUG-seq: Cost-efficient HTTx Platform Enabling Gene Isoforms and non-coding RNA Analysis for MoA Discovery and Risk Assessment
MERCURIUSTM Total DRUG-seq is an early multiplexing protocol that provides full-length gene body coverage from extraction-free RNA, enabling isoform detection, alternative promoter usage, and splicing event analysis, while maintaining high sensitivity with as few as 2’000 cells.
Fast and highly sensitive full-length scRNA-sequencing FLASH-seq
MERCURIUS™ FLASH-seq provides full-length mRNA transcript coverage even for low-abundance genes, empowering researchers to explore differential gene expression, detect alternative splicing, and analyze isoform diversity—all critical for understanding complex biology, especially in rare cell populations. This technology is now accessible to all laboratories, regardless of whether they have an automation system.
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