Alithea Genomics
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Explore publications, scientific posters, application notes, webinars, and other resources related to our technologies.
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- 3' BRB-seq, BRB-seq
Maxine Leonardi, Yves Paychère, Felix Naef.
Alexandre Coudray, Silja Placzek, Marine Vallez, Alix Buu Hoang, Vincent Hahaut and Daniel Alpern
- 1536 DRUG-seq, DRUG-seq
Elodie Koenig, Mark Ofield, Adam Peall, Elizabeth Bourne, Humberto Ferreira, Ji Hoon Han, Silja Placzek, Marine Vallez, Vincent Hahaut, Riccardo Dainese, Daniel Alpern
- 3' BRB-seq, BRB-seq
Yunhee Jeong, Benjamin Buer, Nicolas Arning, Tabea Schlemeyerb, Luigi Di Vierto, Alix Buu Hoang, Sven Geibel
- DRUG-seq, Total DRUG-seq
This paper demonstrates how paired-end sequencing of multiplexed RNA-seq libraries that is currently only possible on AVITI™ systems, boosts transcript detection rate while uncovering physiologically-relevant promoter switching events.
- FLASH-seq, Low-input FLASH-seq, Single-cell FLASH-seq
- 3' DRUG-seq, DRUG-seq
- 3' BRB-seq, BRB-seq
Larissa Carvalho Costa, Christopher Gottschalk, Davis M. Upchurch, Oscar P. Hurtado-Gonzales, Ben N. Mansfeld, Alan Yocca, Lauren Whitt, Cheryl Vann, Gennaro Fazio
- 1536 DRUG-seq, DRUG-seq
In this tech note, we showcase the technical performance of MERCURIUS™ 1536 DRUG-seq and suggest that this AI-ready, automatable, transcriptomic data generation technology can help AI-enabled drug discovery teams build extensive perturbation data moats that give adopters the competitive advantage needed to improve foundational model performance and experimentally assess AI-native predictions.
- 1536 DRUG-seq
For the first time, 1536-well whole transcriptome profiling brings biologically rich readouts to primary screening and large-scale perturbation dataset generation.
- 3' DRUG-seq, DRUG-seq
Max Blanck, Anna Habryka-Pawlowska, Joanna Bird, David Sorrell, Silja Placzek, Vincent Hahaut
- 1536 DRUG-seq, DRUG-seq
A 33-compound study demonstrating reproducible transcriptomic profiling at 1536-well scale, with gene-level resolution of mechanisms of action, toxicity pathways, and dose-dependent responses.
From One Cell to Systems Biology: How Scalable Transcriptomics Is Driving the Bold Future of Single-Cell Multi-Omics
- 1536 DRUG-seq, 3' DRUG-seq, DRUG-seq, Full-length DRUG-seq, Spheroid DRUG-seq, Total DRUG-seq
Learn how to transform DRUG-seq data from raw FASTQ files into reliable biological insights. This webinar covers quality control, differential expression analysis, reproducibility, and pathway scoring. Presented by Alexandre Coudray, Senior Data Scientist at Alithea Genomics.
- FLASH-seq, Single-cell FLASH-seq
Andrea Salati, Yves Paychère, Vincent Hahaut, Cédric Gobet, Felix Naef
- Total BRB-seq
MERCURIUS™ Total BRB-seq versus NEBNext® and Watchmaker library preparation kits for total RNA: 20,000+ genes and 100,000+ transcripts at 5M reads/sample; 5,557 shared DE genes across methods; a moderate sensitivity trade-off for a multiplexed, lower-cost workflow.
- DRUG-seq, Spheroid DRUG-seq
Anstett, V.; Heinzelmann, E.; Piraino, F.; Roch, A.; Chrisnandy, A.; Norkin, M.; Garnier, V.; Homicsko, K.; Hoehnel-Ka, S.; Brandenberg, N.
- 3' BRB-seq, BRB-seq
Austeja Butkute, Marius Baltramonaitis, Simona Malmige, Adas Darinskas, Vita Pasukoniene, Agata Mlynska.
- FLASH-seq, Single-cell FLASH-seq
Akisawa Satomi, Riho Saito, Tadahaya Mizuno, Hiroki Sugishita, Hideki Ukai, Shigeyuki Shichino, Masashi Yanagisawa, Kouji Matsushima, Yukiko Gotoh, Tomohiko Okazaki.
- FLASH-seq, Single-cell FLASH-seq
Tarek Elmzzahi, Chun-Hsi Su, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, DaryaMalko, Maren Koehne, Aleksej Frolov, Teisha Mason, Yuanfang Li, Rebekka Scholz, Collins Osei-Sarpong, Leonie Heyden, Jonas Schulte-Schrepping, Lorenzo Bonaguro, Kristian Haendler, Vassiliki Boussiotis, Annett Halle, Elena De Domenico, Daniel HDGray, Martin Fuhrmann, Zeinab Abdullah, Axel Kallies, Kevin Man, Marc D. Beyer.
- Blood BRB-seq, BRB-seq
Valentin Beauvais, Clémence Couton Nicolò Tonci, Sébastien, Limet, Lucile Mollet, Thierry Prazuck and Sophie Robert.
- 3' BRB-seq, BRB-seq
Wu, C., Wang, T., Ghosh, A. et al.
- 3' BRB-seq, BRB-seq
Pham, C.N., Castelli, F., Finet, F., Leroy, C., Chollet, C., Chirayath, T.W., Moitra, S., Zarka, M., Ostertag, A., Brial, F., Combes, C., Latourte, A., Bardin, T., Fenaille, F., Richette, P. and Ea, H.K.
- FLASH-seq, Single-cell FLASH-seq
V.Hahaut, M.D. Rumper, Q. Zhou
- DRUG-seq, Total DRUG-seq
Overview of the data from MERCURIUS™ Total DRUG-seq: an early multiplexing protocol that provides full-length gene-body coverage from extraction-free RNA, enabling isoform detection, alternative promoter usage, and splicing event analysis, while maintaining high sensitivity with as few as 2’000 cells.
- DRUG-seq
Jack Taylor, Juliette Fernandez, Max Blanck, Anna Habryka-Pawlowska, Andrei Smid, Alix Buu Hoang, Silja Placzek, Vincent Hahaut, Luke Custerson, Hennique Erasmus, Katie Williams, Helen Pemberton, Simon Scrace and David Sorrell
- 3' DRUG-seq, DRUG-seq
Alexandre Coudray, Andrea Hadjikyriacou, Riccardo Dainese, Daniel Alpern
- 3' BRB-seq, BRB-seq
Panos G. Ziros, Dionysios V. Chartoumpekis, Ilias Georgakopoulos-Soares, Georgios Psarias, Gerasimos P. Sykiotis.
- 3' BRB-seq, BRB-seq
Stéphanie Boder‐Pasche, Mustafa Demir, Sarah Heub, Manon Garzuel, Réal Ischer, Daniel Migliozzi, Siegfried Graf, Noa Schmid, H. Baris Atakan, Daria Gudkova, Daniel Alpern, Riccardo Dainese, Bart Deplancke, Gilles Weder
- 3' BRB-seq, BRB-seq
Mitra Gultom, Lin Lin, Camilla Blunk Brandt, Anastasia Milusev, Alain Despont, Jane Shaw, Yvonne Döring, Yonglun Luo, Robert Rieben.
- 3' BRB-seq, BRB-seq
Catherine Martin, Bertrand Evrard, Frédéric Percevault, Kate Ryder, Thomas Darde, Aurélie Lardenois, Maxim Zhadobov, Ronan Sauleau, Frédéric Chalmel, Yves Le Dréan, Denis Habauzit.
- 3' DRUG-seq, DRUG-seq
Rodrigues Sousa, E., de Brot, S., Zoni, E. et al.
- 3' BRB-seq, BRB-seq
Sofa Pavlou, Stefanie Foskolou, Nikolaos Patikas, Sarah F. Field, Evangelia K. Papachristou, Clive D’ Santos, Abigail R. Edwards, Kamal Kishore, Rizwan Ansari, Sandeep S. Rajan, Hugo J. R. Fernandes, Emmanouil Metzakopian.
- 3' BRB-seq, BRB-seq
Sheng Ying, Brandon Webster, Lina Gomez-Cano, Kiran-Kumar Shivaiah, Qianjie Wang, Linsey Newton, Erich Grotewold, Addie Thompson and Peter K. Lundquist.
- 3' BRB-seq, BRB-seq
Przystal, J. M., Cianciolo Cosentino, C., Yadavilli, S., Zhang, J., Laternser, S., Bonner, E. R., Prasad, R., Dawood, A. A., Lobeto, N., Chin Chong, W., Biery, M. C., Myers, C., Olson, J. M., Panditharatna, E., Kritzer, B., Mourabit, S., Vitanza, N. A., Filbin, M. G., de Iuliis, G. N., Dun, M. D., Koschmann, C., Cain, J. E., Grotzer, M. A., Waszak, S. M., Mueller, S., & Nazarian, J.
- 3' BRB-seq, BRB-seq
Laloli, L., Licheri, M. F., Probst, L., Licheri, M., Gultom, M., Holwerda, M., V’kovski, P., & Dijkman, R.
- 3' BRB-seq, BRB-seq
Mouri, K., Guo, M. H., de Boer, C. G., Lissner, M. M., Harten, I. A., Newby, G. A., DeBerg, H. A., Platt, W. F., Gentili, M., Liu, D. R., Campbell, D. J., Hacohen, N., Tewhey, R., & Ray, J. P.
- 3' BRB-seq, BRB-seq
Ishino, T., Takeno, S., Takemoto, K., Yamato, K., Oda, T., Nishida, M., Horibe, Y., Chikuie, N., Kono, T., Taruya, T., Hamamoto, T., & Ueda, T.
- BRB-seq
Hu, T., Todberg, T., Andersen, D., Danneskiold-Samsøe, N. B., Hansen, S. B. N., Kristiansen, K., Ewald, D. A., Brix, S., Rosa, J. C. d., Hoof, I., Skov, L., & Litman, T.
- 3' BRB-seq, BRB-seq
Hirai, S., Tomimatsu, K., Miyawaki-Kuwakado, A., Takizawa, Y., Komatsu, T., Tachibana, T., Fukushima, Y., Takeda, Y., Negishi, L., Kujirai, T., Koyama, M., Ohkawa, Y., & Kurumizaka, H.
- 3' BRB-seq, BRB-seq
Lalli, M., Yen, A., Thopte, U., Dong, F., Moudgil, A., Chen, X., Milbrandt, J., Dougherty, Joseph D., & Mitra, Robi D.
- FLASH-seq, Single-cell FLASH-seq
Hahaut, V., Pavlinic, D., Carbone, W et al.,
- 3' BRB-seq, BRB-seq
Giacosa, S., Pillet, C., Séraudie, I., Guyon, L., Wallez, Y., Roelants, C., Battail, C., Evrard, B., Chalmel, F., Barette, C., Soleilhac, E., Fauvarque, M.-O., Franquet, Q., Sarrazin, C., Peilleron, N., Fiard, G., Long, J.-A., Descotes, J.-L., Cochet, C., & Filhol, O.
- 3' BRB-seq, BRB-seq
Bast-Habersbrunner, A., Kiefer, C., Weber, P., Fromme, T., Schießl, A., Schwalie, P. C., Deplancke, B., Li, Y., & Klingenspor, M.
- 3' BRB-seq, BRB-seq
Kaya-Çopur, A., Marchiano, F., Hein, M. Y., Alpern, D., Russeil, J., Luis, N. M., Mann, M., Deplancke, B., Habermann, B. H., & Schnorrer, F.
- 3' BRB-seq, BRB-seq
Litovchenko, M., Meireles-Filho, A. C. A., Frochaux, M. V., Bevers, R. P. J., Prunotto, A., Anduaga, A. M., Hollis, B., Gardeux, V., Braman, V. S., Russeil, J. M. C., Kadener, S., dal Peraro, M., & Deplancke, B.
- 3' BRB-seq, BRB-seq
Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma.
Christian, W. T., Tiphaine, O.-M., Nava, E., Christian, H., Federico, A. S., Jonathan, N., Dominique, C., Cécile, G., Laurence, M., Sophia, S. W., Shehnaz, K. H., Ioannis, T., Matthias, C., Andri, R., Manuel, B., Matthias, H., Patrick, S., Enos, B., Huldrych, F. G., Pejman, M., Paul, J. M., Charles, S. R., Caroline, B., & Jacques, F.
- 3' BRB-seq, BRB-seq
Frochaux, M. V., Bou Sleiman, M., Gardeux, V., Dainese, R., Hollis, B., Litovchenko, M., Braman, V. S., Andreani, T., Osman, D., & Deplancke, B.
- 3' BRB-seq, BRB-seq
Liu, J., Frochaux, M., Gardeux, V., Deplancke, B., & Robinson-Rechavi, M.
- 3' BRB-seq, BRB-seq
Weger, M., Alpern, D., Cherix, A., Ghosal, S., Grosse, J., Russeil, J., Gruetter, R., de Kloet, E. R., Deplancke, B., & Sandi, C.
- 3' BRB-seq, BRB-seq
Yuan, C., Pan, Z., Zhao, K., Li, J., Sheng, Z., Yao, X., Liu, H., Zhang, X., Yang, Y., Yu, D., Zhang, Y., Xu, Y., Zhang, Z.-Y., Huang, T., Liu, W., & Ouyang, H.
- 3' BRB-seq, BRB-seq
Bevers, R. P. J., Litovchenko, M., Kapopoulou, A., Braman, V. S., Robinson, M. R., Auwerx, J., Hollis, B., & Deplancke, B.
- 3' BRB-seq, BRB-seq
Okada, H., Yagi, R., Gardeux, V., Deplancke, B., & Hafen, E.
- 3' BRB-seq, BRB-seq
Ma, D., Bou-Sleiman, M., Joncour, P., Indelicato, C.-E., Frochaux, M., Braman, V., Litovchenko, M., Storelli, G., Deplancke, B., & Leulier, F.
Li, Y., Schwalie, P. C., Bast-Habersbrunner, A., Mocek, S., Russeil, J., Fromme, T., Deplancke, B., & Klingenspor, M.
Schwalie, P. C., Dong, H., Zachara, M., Russeil, J., Alpern, D., Akchiche, N., Caprara, C., Sun, W., Schlaudraff, K.-U., Soldati, G., Wolfrum, C., & Deplancke, B.
- 3' DRUG-seq, DRUG-seq, Total DRUG-seq
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