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How does BRB-seq compare to SCRB-seq?

Novel sequencing technologies based on the 3' barcoding of mRNA now enable transcriptomic studies...
Written by Riccardo Dainese
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Large-scale RNA-seq series Ep. 6 – Sex Impacts Gene Expression, but not the way you think!

In 2020, the Genotype-Tissue Expression (GTEx) Consortium published seminal findings about how sex...
Written by Riccardo Dainese
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Large-scale RNA-seq series – Ep. 5. – Gene expression networks control organ development across species

In one of the largest studies of its kind, researchers used bulk RNA-seq to decode the gene...
Written by Riccardo Dainese
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Large-scale RNA-seq series – EP.3: ‘Multi-omics’ improves the classification of 33 different cancer types using 10,000 tumor samples.

In 2018 The Cancer Genome Atlas (TCGA) published groundbreaking findings from the largest...
Written by Riccardo Dainese
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Large-scale RNA-seq series Ep. 4: BRB-seq uncovers novel features of fruit fly embryogenesis

A recent publication has used Bulk RNA Barcoding and sequencing (BRB-seq) to investigate one of the...
Written by Riccardo Dainese
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BRB-seq in cancer therapeutics: differential gene expression elucidates the molecular mechanisms of high-grade pediatric gliomas

Diffuse midline gliomas: background and emerging therapies
Written by Riccardo Dainese
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Large-scale RNA-seq series - Ep.2: Predicting cancer outcomes by estimation of tumor specific total mRNA levels in bulk RNA-seq

A recent ground-breaking study uses a mathematical approach to measure tumor-specific total mRNA...
Written by Riccardo Dainese
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BRB-seq pipeline – downstream analysis best practices

In this post, we will see briefly how to perform downstream analysis for RNA-seq data.
Written by Riccardo Dainese
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Large-scale RNA-seq series - Ep.1: RNA-seq helps uncover the genetic regulation of blood cells

The largest blood cell genotyping and transcriptomic study ever performed has shown that a much...
Written by Riccardo Dainese
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COVID-19 under the BRB-Seq microscope: A Tale of Two Coronaviruses

RNA sequencing (RNA-seq) provides a molecular snapshot of the cellular transcriptome, offering a...
Written by Riccardo Dainese
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How do BRB-seq pre-processing results look like?

In this post, we will see briefly how BRB-seq libraries are processed, and what are the...
Written by Riccardo Dainese
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BRB-seq vs Truseq

Despite its widespread use, RNA-seq is still too laborious and expensive to replace RT-qPCR as...
Written by Riccardo Dainese