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Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning – McCrea and Batorsky et al. [1] Published May 9th, 2025,…
DRUG-seq, first published in 2018, has transformed how pharmaceutical, cosmetics, agritech, and AI drug discovery companies screen compounds for on- and off-target effects, mechanisms of…
In recent years, the convergence of CRISPR gene editing and high-throughput screening methodologies has revolutionized genomic research. While the toolkits to edit individual genes have…
As a researcher performing large-scale drug-discovery, genetic perturbation, or toxicogenomic screens, probe-based targeted gene expression profiling assays like Templated Oligo assay with Sequencing (TempO-seq™) from…
Determining the most suitable transcriptomic technology to drive your large-scale compound screen, clinical study, or to assess a panel of genetic perturbations can be a…
Understanding the transcriptomic impacts of new compounds on cells is essential in drug development and toxicology. This process helps researchers evaluate a drug’s on- or…
RNA sequencing (RNA-seq) is an indispensable tool in the drug development pipeline, enabling researchers to explore gene expression profiles, uncover mechanisms of action, and identify…
With a growing number of published 3’ mRNA-seq methods now available, researchers have more choices than ever for high-throughput and cost-effective transcriptomic screening. While broadly…
3’ mRNA-seq technologies are gradually revolutionizing high-throughput bulk transcriptomics.
…For researchers in pharma, biotech, or academia looking to uncover the mechanisms of action, cytotoxicity, or possible on- and off-target effects of drugs in their…
For researchers performing drug discovery, drug repurposing, toxicogenomic screens, or CRISPR screens, the end goal is often to uncover mechanisms of action, determine on- and…
The Joint Undertaking in Morphological Profiling-Cell Painting Gallery (JUMP-CP) is a large-scale, high-content imaging reference dataset created with the Cell Painting technology that assesses the…
Large-scale perturbational profiling is time and cost-intensive, so it’s crucial to compare the capabilities of different technologies to help plan and design experiments efficiently.
…DRUG-seq is a cost-effective, high-throughput bulk RNA-seq library preparation method for compound screening in drug discovery and development (Ye et al., 2018; Li et al.,…
MERCURIUS™ DRUG-seq is a rapid, cost-effective, RNA-extraction-free bulk 3’ mRNA-seq method. It provides ultra-high-throughput studies, such as drug discovery and toxicogenomic screens, with unbiased, transcriptome-wide…
DRUG-seq is a novel high-throughput, cost-effective RNA-seq method for drug discovery (Ye et al., 2018; Li et al., 2022). Researchers have used DRUG-seq and similar…
Determining the transcriptomic effects of novel compounds on cells for large-scale therapeutic or toxicology screens is a critical component of drug development pipelines, allowing researchers…
Microarray-based Clariom™ assays from Applied Biosystems™ are a potential option for gene expression profiling studies when looking for a scalable technology to integrate into drug…
Probe-based gene expression profiling methods, such as Affymetrix™ GeneChip™ microarrays, QuantiGene™ Plex assays from Invitrogen™, and more recently the Clariom™ GO Screen, were a mainstay…
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